Dayong Jin

Biography

Dr. Jin received his BSc. degree in Physics followed by postgraduate study in Optoelectronics Engineering at Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, before moving to Macquarie University in 2003. In 2006 he completed his PhD research under the supervision of Professor James Piper within the Centre for Lasers and Applications @ Macquarie University. Dr. Jin’s PhD research was focused on developing a practical time-gated luminescence flow cytometer for rapid detection of pathogens. As a significant breakthrough in cytometry science, he introduced novel concepts to flow cytometry in time-gated pulsed modes (“time-gated fluorescence flow cytometry” US patent). Two of his recent publications have been selected as key focus publications in 2007 Oct. Issue of the prestigious analytical cytology journal “Cytometry”. As recognition of his research, he won three Macquarie Annual Innovation Awards in 2006 (Innovation Disclosure Award; Postgraduate Award; and Innovative Research Award). He also received Vice-Chancellor Commendations in 2004 and 2006. On 18th June 2007, he was elected as “an ISAC scholar” by the International Society for Analytical Cytology (ISAC) as one of the Emerging Young Scientists to promote cytology research network in Australia-Asia regions. He has been serving the Education and Training Committee of the ARC/NHMRC FABLS network (Fluorescence Applications in Biotechnology and Life Sciences) .

In May 2008, Dr. Jin was appointed as a Macquarie University Research Fellow (MQRF) working in biophotonics science underpinning analytical cytology. Realising that flow cytometry requires multidisciplinary approaches, he has been developing his international research network with both academics and industry. He is a visiting scholar to Dalian University of Technology (Prof. Jingli Yuan’s group), Newport Instruments (Dr. Robert Leif’s group) and Purdue University Cytometry Labs (Prof. J. Paul Robinson’s group). Dr. Jin’s present projects belong to the cross-disciplinary area of Biophotonics including flow cytometry, fluorescence microscopy, time-gated luminescence for biomedical applications, and nanoparticle biosensors. Dr. Jin seeks suitable PhD candidates (including joint university degrees) for scholarship applications available from either Macquarie University Research Excellence Scholarship (MQRES) or China Scholarship Council (CSC), or Fudan University - Macquarie University Joint University PhD Scholarship.

In 2009 Dr. Jin has been appointed as a Lecturer, then a prestigious APD Research Fellow by Australian Research Council (2010 ~ 2012) for a Discovery Project “Novel coding and decoding in suspension arrays for accelerated biomolecular discovery and personalised medicine”. Through his international research network, his team will establish an advanced multiplexing technique to rapidly analyse complex biological mixtures, such as cell lysates, food samples or body fluids. It will enable the analysis of not tens, but thousands or more distinctive molecular targets in a single test. This will build the foundations for future generation bioassays, paving the way to emerging personalised medicine. This will lead to new personal diagnostics tools for rapid genotype profiling, to better tailor therapy to the individual patient's specific characteristics. As well as the potential to improve health outcomes, the project will generate significant intellectual property and the opportunity for development of new diagnostic instrumentation in Australia. [A PhD scholarship on this project is also available to a suitable candidate.]

Selected Publications

1. US Patent “time-gated fluorescence flow cytometry” (Jin D, Connally R, Piper J).
2. Provisional Patent “Background-free fluorescence microscopy”  (Jin D, Piper J).
3. Deng W, Drozdowicz-Tomsia K, Jin D, Goldys E, “Enhanced Flow Cytometry Based Bead Immunoassays by Using Metal Nanostructures” (2009) Analytical Chemistry, 81 (17), pp. 7248-7255.  [impact factor: 5.712]
4. Jiang H, Wang G, Liu X, Zhang W, Ye Z, Jin D, Yuan J, Liu Z, “Preparation and Time-Resolved Fluorescence Bioassay Application of Multicolor Fluorescent Lanthanide Nanoparticles” J Fluorescence, DOI 10.1007/s10895-009-0559-7 [impact factor: 1.880]
5. Song CH, Ye ZQ, Wang GL, Jin D, Yuan JL, Guan Y and Piper J, “Preparation and Time-Gated Luminescence Bioimaging Application of Ruthenium Complex Covalently Bound Silica Nanoparticles.” TALANTA, 2009, 79 (1), 103-108. [journal Impact Factor 3.37]
6. R. C. Leif, S. Yang, D. Jin, J. Piper, L. M. Vallarino, J. W. Williams, R. M. Zucker, "Calibration Beads Containing Luminescent Lanthanide Ion Complexes," J Biomedical Optics, Vol. 14, 024022 (Apr. 14, 2009) [journal Impact Factor 3.08]
7. D. Jin, J. Piper, R. C. Leif, S. Yang, B. C. Ferrari, J. Yuan, G. Wang, L. M. Vallarino, J. W. Williams, "Time-gated luminescence flow cytometry: an ultra-high selectivity method to recover ultra-rare-event μ-targets in raw biosamples", J Biomedical Optics, Vol. 14, 024023 (Apr. 14, 2009) [journal Impact Factor 3.08]
8. Wu J, Ye ZQ, Wang GL, Jin D, Yuan JL, Guan Y and Piper J, “Visible-light-sensitized highly luminescent europium nanoparticles: preparation and application for time-gated luminescence bioimaging.” J. Mater. Chem. (2009)19 (9), pp. 1258-1264. [impact factor: 4.646]
9. Wu J, Wang GL, Jin D, Yuan JL, Guan Y, Piper J. (2008) “Luminescent europium nanoparticles with a wide excitation range from UV to visible light for biolabeling and time-gated luminescence bioimaging.” Chem. Commun., 2008:365 - 367. [journal Impact Factor 5.14]
10. Jin D, Connally R, Piper J. (2007) “Practical time-gated luminescence flow cytometry. I: Concepts.” Cytometry Part A, 71A(10):783-796. [journal Impact Factor 3.29]
11. Jin D, Connally R, Piper J. (2007) “Practical time-gated luminescence flow cytometry. II: Experimental evaluation using UV LED excitation.” Cytometry Part A, 71A(10):797-808. [journal Impact Factor 3.29]
12. Jin D, Connally R, Piper J. (2006). “Long-lived visible luminescence of UV LEDs and impact on LED excited time-resolved fluorescence applications.” J. Phys. D-Applied Phys., 39(3):461-465; [11 citations] [journal Impact Factor 2.20]
13. Connally R, Jin D, Piper JA. (2006) “High Intensity Solid-state UV Source for Time-resolved Fluorescence Microscopy” Cytometry Part A: 69A (9): 1020-1027; [journal Impact Factor 3.29]
14. [Invited Talk] D. Jin, J. A. Piper, J. Yuan, R. C. Leif, “Time-gated real-time bioimaging system using multi-colour microsecond-lifetime silica nanoparticles” SPIE Photonics West 2010 BIOS, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues
15. Jin D, Ferrari B, Leif  RC, Yang S, Vallarino LM, Williams J, Piper JA.“UV LED Excited Time-Gated Luminescence Flow Cytometry: Evaluation For Rare-Event Particle Counting” The International Society for Optical Engineering-SPIE proceeding, Volume 6859, 68590O (2008);
16. Leif  RC, Jin D, Piper JA, Vallarino LM, Williams J, Yang S, Zucker RM. “ Calibration Beads Containing Luminescent Lanthanide Ion Complexes” The International Society for Optical Engineering-SPIE proceeding, Volume 6859, 685917 (2008);
17. Jin D, Connally R, Piper JA.“UV LED excited time-gated luminescence flow cytometry: concepts and experimental evaluation” Smart Medical and Biomedical Sensor Technology - SPIE proceeding: Vol 6380, 63800L (2006).
18. Jin D, Connally R, Piper JA.“Ultrasensitive time-resolved nanoliter volume fluorometry based on UV LEDs and a channel photomultiplier tube.” The International Society for Optical Engineering-SPIE proceeding: Vol 5704, pp. 93-104 (2005).
19. Connally R, Jin D, Piper JA.“BHHST: An improved lanthanide chelate for time-resolved fluorescence applications.” The International Society for Optical Engineering-SPIE proceeding: Vol 5699, pp 93-104 (2005).